Vuris mess with the DNA-RNA-protein model that is a major tenet of biology
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Different viruses progress differently after they infect you - graphs on the way
Consequences of viral infections:
* Some are fatal
* Some related to congenital diseases
* Contributory factor to cancer (like HPV --> cervical cancer)
* COntribute to other diseases
* Economic impact
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*Some viruses asymptomatic - not all viruses make you sick
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Pathogenesis: *how* viruses cause disease
Eyes, mouth, skin [abrasion, injection], respiratory tract, alimentary canal, urogenital tract, anus
^ Different viruses target different areas
Attachment: Some viruses work with a cell receptor unique to a specific type of cell.
Once attached, virus gets thorugh the cell membrane and inside the cell
The few genes/proteins in a virus genome aren't enough to do what it needs to do, so it gets that by hijacking the host cell.
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Vesicular Stomatitis Virus
Preferred host: cattle
Can target other organisms if the virus is in a larger concentration
Can kill a cow in about a week
Only has 5 proteins
RNA degrades pretty quickly in the open environment, N-protein of VSV guards it.
Can easily add a 'tracking' gene (i.e. staining/coloration)
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Virus invasion of a cell triggers the cell to produce "interferon" (cellular distress call)
Some viruses interfere with interferon
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