Friday, March 14, 2008

Questions

1 - Inadverntent Vaccination

Vaccines that are modified viruses - problem of *those* being transmitted

* Depends on characteristics of the specific modified virus
* Some people will be more-vulnerable to even a weakened modified virus
* Can address this by heavily customizing the modified virus

2 - VSV and interferon

Why isn't interferon beign released form VSV-infected cells?
Does this have anything to do with interferon.

Either VSV isn't inducing interferon, or it;s stopping interferon that is getting released.

3 - What if the vaccination causes a disease?

* The question addressed by Phase I clinical trials (giving vaccine to previously-healthy people)

* The question of pharmacology: the risk/reward analysis

4 - Sanitation

* If over-sanitation is increasing susceptibilty to some diseases, should we consciously tone it down?

Yes.
Well, not in a hospital environment
* Natural flora - body has loads of "good" bacteria and viruses in it at any one time.
Don't want to kill those.

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